Francesco De Bonis (born 14 April 1982 in Isola del Liri) is an Italian former professional road cyclist. In 2008 he won the fourth stage and the mountains classification of the Tour de Romandie. He also rode in the 2009 Giro d'Italia, finishing 79th overall.

On 27 May 2010, based on discrepancies in his biological passport, De Bonis was suspended for two years by the Italian Olympic Committee after a request from the International Cycling Union.