Simon Clarke (born 18 July 1986) is an Australian former professional road racing cyclist, who last rode for UCI WorldTeam NSN Cycling Team. He previously rode for the Astana (2011) and Orica–GreenEDGE (2012–2015) teams in the UCI World Tour. Before turning professional, Clarke competed in track cycling as an Australian Institute of Sport scholarship holder. He is not related to fellow Australian cyclist and past teammate Will Clarke.

After retiring from professional cycling after the 2026 Cadel Evans Great Ocean Road Race, Clarke joined his team's performance staff.