David or Dave Knight may refer to:

• David Knight (American football) (born 1951), former American football player
• David Knight (CND), chair for the Campaign for Nuclear Disarmament 1996–2001
• David Knight (cricketer) (born 1956), Australian cricketer
• David Knight (English footballer) (born 1987), English footballer
• David Knight (motorcyclist) (born 1978), enduro rider from the Isle of Man
• David Knight (musician) (born 1978), American singer and music composer
• David Knight (politician) (born 1969), state representative in the U.S. state of Georgia
• David L. Knight (New Hampshire politician) (1950–2007), state representative in the U.S. state of New Hampshire
• David M. Knight (1936–2018), English professor of history and philosophy of science
• Dave Knight, American slalom canoeist
• Dave Knight (baseball), American baseball player
• Dave Simpson (soccer) (born 1983), David Simpson Knight, Canadian soccer player
• Tuffy Knight (born 1936), David "Tuffy" Knight, Canadian football coach