Gilberto Simoni (born 25 August 1971) is an Italian former professional road bicycle racer, most recently for Lampre–Farnese Vini. Simoni won the Giro d'Italia cycling race twice: once in 2001 and again in 2003. In 2002 he tested positive for cocaine and was withdrawn from the race by his Saeco team; he was later cleared of any doping violation by the Italian Cycling Federation. Aside from his withdrawal in 2002, he finished on the podium in every other Giro between 1999 and 2006.

Simoni is a native of Palu di Giovo, and was considered a climbing specialist. His final race as a professional road cyclist was the 2010 Giro d'Italia, which he finished in 69th place overall, 2:40:14 behind other two-time winner, Ivan Basso.