• The Simoni people were a Native American group in Texas.

Simoni is a surname, and may refer to:

• Alexandre Simoni (born 1979), Brazilian tennis player
• Dario Simoni (1901–1984), American set decorator
• Elisa Simoni (born 1973), Italian politician
• Ernest Simoni (born 1928), Albanian Roman Catholic cardinal
• Giampiero Simoni (born 1969), Italian racing driver
• Gilberto Simoni (born 1971), Italian professional road bicycle racer
• Giuseppe Simoni (born 1944), Italian biologist and scientist
• Gjon Simoni (1936–1999), Albanian musicologist and composer
• Jane M. Simoni, American clinical psychologist
• Luigi Simoni (1939–2020), Italian football manager
• Renato Simoni (1875–1952), Italian journalist
• Sabrina Simoni (born 1969), Italian conductor
• Simone Simoni (1532–1602), Italian philosopher and physician
• Ugo Simoni (born 1938), Italian former sports shooter
• Zef Simoni (1928–2009), Albanian Roman Catholic bishop