Sam Watson may refer to:

• Samuel Watson (sculptor) (1662–1715), sculptor in wood and stone
• Samuel Watson (horologist) (fl. c. 1687–c. 1710), Sheriff of Coventry and manufacturer of the first stopwatch
• Samuel C. Watson (1832–1892), US druggist, doctor, and civic leader
• Samuel E. Watson (died 1847), U.S. Marine Corps officer
• Sam Watson (trade unionist) (1898–1967), English coalminers' leader
• Samuel William Watson (1952–2019), Aboriginal Australian novelist, filmmaker and political activist
• Sam Watson, 1966 Irish winner of Fitchburg Longsjo Classic bicycle race
• Samuel Wagan Watson (born 1972), Aboriginal Australian poet
• Sam Watson (equestrian) (born 1985), Irish equestrian
• Sam Watson (politician), US politician