Patrick Lefevere (born 6 January 1955) is a Belgian retired professional cyclist, who formerly served as the general manager of UCI WorldTeam Soudal–Quick-Step. The outspoken Lefevre was the driving force behind one of the most successful cycling teams in the world for more than 20 years.

Under Lefevere's leadership, the team celebrated almost a thousand victories, including 22 Monuments, 124 stages in the Grand Tours Tour de France, Giro d'Italia and Vuelta a España and 19 world titles.

According to the ranking site Cycling Ranking he is the most successful cycling manager in history.