Senn is a term for the chief herdsman tending an Alp. As a surname:

• Alfred E. Senn (1932–2016), professor emeritus of history at the University of Wisconsin–Madison
• Bill Senn (1905–1973), professional American football running back in the National Football League
• Chris Senn (skateboarder) (born 1972), professional skateboarder, known for his aggressive and spontaneous style
• Daniel Senn (born 1983), Swiss footballer
• Deborah Senn, Washington politician
• Frank Senn (born 1943), American Lutheran pastor and liturgiologist
• Franz Senn (1831–1884), pastor, whose concern for the poverty of his parishioners lead him to encourage tourism into the Stubai
• Gustav Senn (1875–1945), Swiss botanist
• Hans Senn (1918–2007), general officer of the Swiss Army
• Jean Antoine Petit-Senn (1792–1870), poet of French-Swiss origin
• Johann Senn (1795–1857), political lyric poet of the Vormärz
• Jordan Senn (born 1984), American football linebacker
• Mark Senn (1878–1951), Conservative and Progressive Conservative party member of the Canadian House of Commons
• Nicholas Senn (1844–1908), surgeon, instructor, and founder of the Association of Military Surgeons of the United States
• Nikolaus Senn (1926–2014), former co-director of Schweizerische Bankgesellschaft
• Reinhold Senn (1936–2023), Austrian luger who competed during the 1960s
• Ricardo Senn (1931–2012), retired track and road bicycle racer from Argentina
• Thomas J. Senn, American naval officer and 1891 graduate of the United States Naval Academy