Hennequin is a French surname. Notable people with the surname include:

• Alfred Hennequin (1842–1887), Belgian dramatist
• Benjamin Hennequin (born 1984), French weightlifter
• Daniel Hennequin (born 1961), French physicist
• Denis Hennequin (born 1958), French businessman
• Emile Hennequin (1859–1888), a French philosopher
• Philippe-Auguste Hennequin (1762–1833), French painter
• Victor Hennequin, French medium
• Paul Hennequin (born 2002), French cyclist