Clerc is a French surname. Notable people with the surname include:

• Albert Clerc, French chess player
• Aurélien Clerc, Swiss cyclist
• François Clerc, French footballer
• José Luis Clerc, Argentine tennis player
• Julien Clerc, French singer
• Laurent Clerc, teacher, co-founder of the first school for the deaf in North America
• Maurice Clerc (mathematician), French mathematician
• Maurice Clerc (organist), French organist
• Mialitiana Clerc (born 2001), Malagasy alpine skier
• Onésime Clerc, Swiss born Russian naturalist
• Vincent Clerc, French rugby union player