Frans Melckenbeeck (15 November 1940 – 28 October 2025) was a Belgian professional road bicycle racer. In 1962, Melckenbeeck won one stage of the Tour de France, and in 1963 he won Liège–Bastogne–Liège. He won four stages in the 1964 and 1965 Vuelta a España. Melckenbeeck also competed in the team pursuit at the 1960 Summer Olympics.

In total, Melckenbeeck collected 240 victories, 64 of which as a professional rider. He also achieved success on the cycling tracks.

A cycling race, the Grand Prix Frans Melckenbeek, is organized every year in his hometown of Lede. In 2018, Melckenbeeck became an honorary citizen of the municipality.

Melckenbeeck died on 28 October 2025, at the age of 84.