Antoine Duchesne (born September 12, 1991) is a Canadian former cyclist, who competed as a professional from 2013 to 2022.

In May 2015, Duchesne helped his teammate Bryan Coquard to victory on the first stage of the Four Days of Dunkirk, especially in the finale where he took long pulls in the leading group, setting his teammate up for the win. He was named in the start list for the 2015 Vuelta a España and the 2016 Tour de France.