Edoardo Affini (born 24 June 1996) is an Italian professional road cyclist who rides for UCI WorldTeam Visma–Lease a Bike. A specialist in time trials and a versatile rouleur, he has represented Italy at multiple European and World Championships, winning titles in both individual and mixed relay events. Affini is the reigning European time trial champion, having previously won the under-23 title in 2018, and has also earned multiple medals in the mixed team relay at world level.

Affini turned professional with Mitchelton–Scott in 2019 following a successful under-23 career with SEG Racing Academy, during which he won stages at the Tour of Norway and Tour of Britain, as well as the Mediterranean Games time trial. In 2021, he joined Team Jumbo–Visma (now Visma–Lease a Bike), establishing himself as a key domestique and team time trialist. He has ridden multiple editions of the Giro d'Italia, contributed to team time trial victories at Grand Tours, and in 2025 was selected for his debut in the Tour de France.