Nathan Van Hooydonck (born 12 October 1995) is a Belgian cyclist, who currently rides for UCI WorldTeam Team Jumbo–Visma.

In August 2019, he was named in the startlist for the 2019 Vuelta a España. In 2021 he entered his second edition of the Vuelta, his first riding for Team Jumbo-Visma. He rode in support of Primož Roglič, who won the race. He was named to the team for the 2022 Tour de France and ended up playing an important role. Between Roglič, Vingegaard and van Aert fighting for stage wins, jerseys and the Tour de France itself, Van Hooydonck was one of the domestiques doing whatever was asked of him for the team. He had to leave the race just two stages before the end, due to a personal matter beyond his control.

He is the son of former professional cyclist Gino and the nephew of two-time Tour of Flanders winner Edwig Van Hooydonck.