Davide Appollonio (born 2 June 1989) is an Italian professional road bicycle racer, currently suspended from the sport for an anti-doping violation. Appollonio first made an impression in the professional ranks riding as a stagiaire for Cervélo TestTeam during the latter part of 2009, before signing for the team as a neo-pro for the 2010 season.
He joined Team Sky for the 2011 season, picking up his first win for the team on the 3rd stage of the Tour de Luxembourg, and then his first overall Sprints competition the following day. Appollonio left Team Sky at the end of the 2012 season, and joined Ag2r–La Mondiale on a two-year contract from the 2013 season onwards. In October 2014 he announced that he would join Androni Giocattoli for 2015, the first time Appollonio has joined an Italian professional cycling team.
On June 30, 2015, Appollonio gave an adverse analytical finding for EPO, on June 14 – two weeks after completing the Giro d'Italia, and was provisionally suspended.