Matthew Busche (born May 9, 1985) is an American former professional road racing cyclist, who rode professionally between 2009 and 2016 for the Kelly Benefit Strategies, Team RadioShack, Trek Factory Racing and UnitedHealthcare teams. In 2009, he gained notoriety for his rapid rise from a Wisconsin-based amateur team to Team RadioShack within the course of one season. Busche was the winner of the 2011 and 2015 United States National Road Race Championships.