Pavel Padrnos (born 17 December 1970) is a Czech former professional road racing cyclist, most recently with Discovery Channel whom he was with between 2002 and 2007. His major individual success is the win in Peace Race in 1995. He competed at the 1992 Summer Olympics and the 2000 Summer Olympics.

During the 2004 Tour de France the UCI were discussing whether Padrnos and Stefano Zanini of Quick-Step–Davitamon would be allowed to continue the Tour. This was because both riders had been called to appear in a case relating to doping at the 2001 Giro d'Italia. The UCI decided to let the riders continue.