Neilson Powless (born September 3, 1996) is an American professional road racing cyclist, who currently rides for UCI WorldTeam EF Education–EasyPost. Powless, who is Oneida, is the first US Native American to compete in the Tour de France.

In August 2019, he was named in the startlist for the 2019 Vuelta a España. Powless, along with Jumbo-Visma teammates Robert Gesink, George Bennett and Sepp Kuss, each finished between 27th and 33rd in the overall standings en route to assisting Primož Roglič in winning the race.

The next season he changed teams to EF Pro Cycling. In August 2020, he was named on the startlist for the 2020 Tour de France. He rode in support of GC contender and team leader Rigoberto Uran. During this tour he got involved in a breakaway and earned a top 5 stage finish.

Following his strong debut, Powless again was named as part of the EF Team for the 2021 Tour de France. Early in the season he finished 5th in the 2021 UAE Tour, in July he won the 2021 Clásica de San Sebastián, becoming only the second American to do so, and late in the season he finished 5th in the UCI world championship.